منابع مشابه
Endothelial/pericyte interactions.
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiova...
متن کاملNeutrophil-Endothelial Cell Interaction
Methods Bovine microvascular endothelial cells (MEC) were able to degrade the H202 generated by phorbol myristate acetate-activated bovine neutrophils or by glucose oxidase with a maximal capacity of 4.0±1.2 (SD) nmol/10' cells/min, corresponding to the H202 released by about 3 X 10' neutrophils. H202 degradation occurred via the glutathione redox cycle and catalase. Degradation via the glutath...
متن کاملInfluence of Morphine on Pericyte-Endothelial Interaction: Implications for Antiangiogenic Therapy
Morphine stimulates tumor angiogenesis and cancer progression in mice. We examined if morphine influences endothelial-pericyte interaction via platelet-derived growth factor-BB (PDGF-BB) and PDGF receptor-β (PDGFR-β). Clinically relevant doses of morphine stimulated PDGF-BB secretion from human umbilical vein endothelial cells and activated PDGFR-β and mitogen-activated protein kinase/extracell...
متن کاملThe role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation.
AIMS Aberrant retinal blood flow is a hallmark of various retinopathies and may be a causative factor in the pathology associated with these conditions. We examined the effects of pulsatile flow on bovine retinal endothelial cell (BREC) and bovine retinal pericyte (BRP) apoptosis and proliferation. METHODS AND RESULTS Co-cultured BRECs and BRPs were exposed to low (0.3 mL/min) or high (25 mL/...
متن کاملCoregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3
The endothelial cell (EC)-derived tissue inhibitor of metalloproteinase-2 (TIMP-2) and pericyte-derived TIMP-3 are shown to coregulate human capillary tube stabilization following EC-pericyte interactions through a combined ability to block EC tube morphogenesis and regression in three-dimensional collagen matrices. EC-pericyte interactions strongly induce TIMP-3 expression by pericytes, wherea...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2012
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.20252